منابع مشابه
Fractalkine: a novel cardiac chemokine?
The endothelium plays a central role in maintaining cardiovascular integrity, function, and the response to injury. A multitude of bioactive molecules is known to be expressed in and secreted from the endothelium under both physiological and pathophysiological circumstances. Xuan et al. uncover a unique role for fractalkine (FKN), a novel membrane-bound chemokine that is mainly expressed in end...
متن کاملFractalkine: one chemokine, many functions.
purification quality of CLP is important, especially for analyses of T-cell development. The original phenotypic CLP has recently been refined by addition of positivity for Flk25 and now a smaller population of cells including CD27 are shown to contain the T-cell potential. A specific criticism of the CLP as the thymus-seeding cell has been the lack of evidence that CLP can be detected in thymu...
متن کاملGeneration and analysis of mice lacking the chemokine fractalkine.
Fractalkine (CX(3)CL1) is the first described chemokine that can exist either as a soluble protein or as a membrane-bound molecule. Both forms of fractalkine can mediate adhesion of cells expressing its receptor, CX(3)CR1. This activity, together with its expression on endothelial cells, suggests that fractalkine might mediate adhesion of leukocytes to the endothelium during inflammation. Fract...
متن کاملFractalkine, a CX3C chemokine, as a mediator of ocular angiogenesis.
PURPOSE Fractalkine (FKN) is a chemoattractant and adhesion molecule for leukocytes. Angiogenic effect of FKN also has been reported. This study was an investigation of FKN-mediated angiogenesis in vitro and in vivo to determine its role in ocular angiogenic disorders. METHODS FKN effects on cultured human umbilical vein endothelial cells (HUVECs) and bovine retinal capillary endothelial cell...
متن کاملLinked chromosome 16q13 chemokines, macrophage-derived chemokine, fractalkine, and thymus- and activation-regulated chemokine, are expressed in human atherosclerotic lesions.
Chemokines are important mediators of macrophage and T-cell recruitment in a number of inflammatory pathologies, and chemokines expressed in atherosclerotic lesions may play an important role in mononuclear cell recruitment and macrophage differentiation. We have analyzed the expression of the linked chromosome 16q13 genes that encode macrophage-derived chemokine (MDC/CCL22), thymus- and activa...
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ژورنال
عنوان ژورنال: Japanese Journal of Clinical Immunology
سال: 2000
ISSN: 0911-4300,1349-7413
DOI: 10.2177/jsci.23.90